DDX39A

Across TCGA pan-cancer cohorts, DDX39A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DDX39A data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DDX39A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DDX39A expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where DDX39A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.490	0.833	<.001	79	view →
LUAD	DFS	Median	II,III,IV	0.961	0.745	.011	13	view →
CCRCC	DFS	Quartile	III,IV	0.536	0.887	.009	13	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
OV	DFS	Median	All	0.676	0.923	.041	8	view →
LSCC	OS	Median	All	1.000	0.926	.017	6	view →
UCEC	DFS	Quartile	All	0.742	0.961	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DDX39A–HNSC (OS)

Open the HNSC breakdown →