DDX39A

Across TCGA patient cohorts, DDX39A mutation is significantly associated with the RNA expression of many other genes, with 660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX39A-associated genes across cancer lineages are MON1A, ATPAF2, and RNASEK. Each is linked with DDX39A in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX39A-to-partner and partner-to-DDX39A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MON1A grouped by DDX39A-low versus DDX39A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX39A→partner) and Y-score (partner→DDX39A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MON1A →	+0.458	+3.818	<.001	<.001	3	2
UCEC	ATPAF2 →	+0.340	+2.754	.003	.002	3	2
UCEC	RNASEK →	+0.325	+3.502	.007	.002	3	2
BRCA	PLCE1P1 →	+0.239	+7.731	<.001	.009	3	1
BRCA	MIR3118-3 →	+0.558	+8.471	<.001	.005	3	1
CESC	RNU6-28P →	+0.416	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 660 associations by consensus.

MON1A by DDX39A expression — UCEC

Explore this box plot interactively →