DDX28

Across TCGA pan-cancer cohorts, DDX28 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DDX28 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DDX28 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DDX28 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where DDX28 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.950	0.687	.004	21	view →
CCRCC	DFS	Tertile	III,IV	0.502	0.843	.016	14	view →
LUAD	DFS	Quartile	III,IV	0.953	0.372	.006	4	view →
LSCC	DFS	Median	II,III,IV	0.826	0.549	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DDX28–PDAC (OS)

Open the PDAC breakdown →