DDX28

Across TCGA patient cohorts, DDX28 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX28-associated genes across cancer lineages are Ku80, MEK1, and Tuberin. Each is linked with DDX28 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX28-to-partner and partner-to-DDX28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DDX28-low versus DDX28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX28→partner) and Y-score (partner→DDX28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.303	+3.183	.019	.010	3	1
UCEC	MEK1 →	+0.400	+3.000	.046	.036	3	1
UCEC	Tuberin →	+0.295	+3.169	.046	.020	3	1
UCEC	Chk2 →	-0.295	-3.169	.022	.020	3	1
UCEC	p62 Lck ligand →	+0.480	+2.817	.007	.036	2	1
UCEC	Notch1 →	+0.253	+3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Ku80 by DDX28 expression — UCEC

Explore this box plot interactively →