DDX28

Across TCGA cell cohorts, DDX28 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDX28-associated genes across cancer lineages are MBL2, DEFB108B, and GUCA2A. Each is linked with DDX28 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX28-to-partner and partner-to-DDX28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBL2 grouped by DDX28-low versus DDX28-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX28→partner) and Y-score (partner→DDX28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MBL2 →	+0.004	+3.684	<.001	.004	3	1
BLOOD_Leukemia	DEFB108B →	+0.106	+3.684	<.001	.004	3	1
BLOOD_Leukemia	GUCA2A →	+0.026	+3.969	<.001	.009	3	1
BLOOD_Leukemia	OR6J1 →	+0.045	+3.234	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.365	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	C4orf51 →	+0.382	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MBL2 by DDX28 expression — BLOOD_Leukemia

Explore this box plot interactively →