DDX27

Across TCGA pan-cancer cohorts, DDX27 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated DDX27 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DDX27 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDX27 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where DDX27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.362	0.759	<.001	98	view →
COAD	DFS	Median	II,III,IV	1.000	0.913	.015	42	view →
LUAD	DFS	Quartile	II,III,IV	0.950	0.607	.007	26	view →
PDAC	DFS	Tertile	III,IV	0.197	0.632	.016	13	view →
LSCC	OS	Quartile	II,III,IV	0.929	0.519	.006	10	view →
GBM	OS	Median	All	0.525	0.225	.011	5	view →
HNSC	OS	Quartile	All	0.690	0.900	.030	5	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DDX27–CCRCC (DFS)

Open the CCRCC breakdown →