DDX23

Across TCGA pan-cancer cohorts, DDX23 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DDX23 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DDX23 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DDX23 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, PDAC, and OV are the cancer types where DDX23 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.885	1.000	.002	13	view →
PDAC	DFS	Median	IV	0.766	0.234	.026	7	view →
OV	DFS	Tertile	All	0.651	1.000	.044	4	view →
HNSC	OS	Quartile	All	0.779	0.963	.014	4	view →
GBM	OS	Median	All	0.539	0.251	.024	4	view →
LUAD	DFS	Tertile	III,IV	0.870	0.429	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DDX23–CCRCC (OS)

Open the CCRCC breakdown →