DDX21

Across TCGA pan-cancer cohorts, DDX21 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX21 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DDX21 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DDX21 expression acts as an unfavorable survival marker.

LUAD, LIHC, and COAD are the cancer types where DDX21 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.054	0.814	<.001	24	view →
LIHC	OS	Median	All	0.156	0.777	.003	12	view →
COAD	OS	Median	All	0.001	0.871	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX21–LUAD (OS)

Open the LUAD breakdown →