DDX21

Across TCGA cell cohorts, DDX21 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible DDX21-associated genes across cancer lineages are LRTM1, TEX55, and GPRC6A. Each is linked with DDX21 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX21-to-partner and partner-to-DDX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRTM1 grouped by DDX21-low versus DDX21-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX21→partner) and Y-score (partner→DDX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LRTM1 →	+0.077	+4.421	<.001	.004	3	1
BREAST	TEX55 →	+0.031	+4.199	<.001	.007	3	1
BREAST	GPRC6A →	+0.028	+4.199	<.001	.007	3	1
BREAST	OR2B3 →	+0.015	+4.781	<.001	.003	3	1
BREAST	NMRK2 →	+0.047	+4.199	<.001	.007	3	1
LUNG_NSCLC_LUAD	COX4I2 →	+0.089	+5.813	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

LRTM1 by DDX21 expression — BREAST

Explore this box plot interactively →