DDX19B

Across TCGA patient cohorts, DDX19B mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX19B-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and ERK2. Each is linked with DDX19B in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX19B-to-partner and partner-to-DDX19B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DDX19B-low versus DDX19B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX19B→partner) and Y-score (partner→DDX19B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.152	+3.341	<.001	.005	3	2
UCEC	eIF4E →	+0.230	+3.584	.024	.002	3	1
UCEC	ERK2 →	+0.248	+2.999	.007	.035	3	1
UCEC	FoxM1 →	+0.337	+3.009	.007	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.246	-3.321	.002	.010	3	1
UCEC	JNK2 →	+0.244	+2.459	.010	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by DDX19B expression — UCEC

Explore this box plot interactively →