DDX19A

Across TCGA patient cohorts, DDX19A mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX19A-associated genes across cancer lineages are GSK-3a-b_pS21_S9, 4E-BP1, and C-Raf. Each is linked with DDX19A in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX19A-to-partner and partner-to-DDX19A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by DDX19A-low versus DDX19A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX19A→partner) and Y-score (partner→DDX19A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.474	+2.469	.005	.010	3	2
UCEC	4E-BP1 →	+0.276	+2.489	.011	.010	3	2
UCEC	C-Raf →	+0.175	+2.415	.002	.003	3	2
UCEC	14-3-3_beta →	-0.122	-3.558	.002	.002	3	1
UCEC	eIF4E →	+0.172	+1.906	.043	.016	3	1
UCEC	Heregulin →	-0.123	-3.459	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GSK-3a-b_pS21_S9 by DDX19A expression — UCEC

Explore this box plot interactively →