DDX18

Across TCGA patient cohorts, DDX18 mutation is significantly associated with the RNA expression of many other genes, with 2,593 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX18-associated genes across cancer lineages are RNU6-1089P, IGHD3-16, and IGHD6-25. Each is linked with DDX18 in more than 3 cancer types. Because this analysis shows association rather than direction, both DDX18-to-partner and partner-to-DDX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1089P grouped by DDX18-low versus DDX18-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX18→partner) and Y-score (partner→DDX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1089P →	+0.471	+2.925	.001	.008	3	4
LIHC	IGHD3-16 →	+0.861	+5.447	<.001	.005	3	3
LIHC	IGHD6-25 →	+1.575	+5.108	<.001	.008	3	3
UCEC	RACGAP1 →	+0.568	+1.534	.003	.005	3	3
UCEC	RN7SL478P →	+0.139	+1.491	.007	.009	3	3
COAD	CHCHD2P1 →	+0.256	+2.861	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,593 associations by consensus.

RNU6-1089P by DDX18 expression — LUAD

Explore this box plot interactively →