DDX18

Across TCGA patient cohorts, DDX18 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX18-associated genes across cancer lineages are Di-Ras3, Heregulin, and JNK2. Each is linked with DDX18 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX18-to-partner and partner-to-DDX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by DDX18-low versus DDX18-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX18→partner) and Y-score (partner→DDX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Di-Ras3 →	-0.233	-3.161	.015	.019	3	3
UCEC	Heregulin →	-0.133	-3.308	.002	.009	3	3
COAD	JNK2 →	+0.246	+3.178	.006	.010	3	2
UCEC	MEK1 →	+0.513	+2.321	<.001	.001	3	2
COAD	PCNA →	+0.297	+3.178	.015	.010	3	2
COAD	Caspase-7-cleavedD198 →	+1.087	+3.178	.005	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Di-Ras3 by DDX18 expression — COAD

Explore this box plot interactively →