DDX18

Across TCGA cell cohorts, DDX18 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,720 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DDX18-associated GO terms across cancer lineages are DNA replication initiation, DNA-templated transcription termination, and DNA-templated DNA replication. Each is linked with DDX18 in more than 17 cancer types. Because this analysis shows association rather than direction, both DDX18-to-partner and partner-to-DDX18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by DDX18-low versus DDX18-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX18→partner) and Y-score (partner→DDX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.181	+1.174	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription termination →	+0.106	+0.875	.001	.004	3	18
BONE	DNA-templated DNA replication →	+0.115	+0.567	.005	.005	3	18
LUNG_NSCLC_LUSC	Transcription by RNA polymerase I →	+0.131	+0.871	.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Interstrand cross-link repair →	+0.085	+1.172	<.001	<.001	3	17
LUNG_NSCLC_LUSC	rRNA 5'-end processing →	+0.161	+0.717	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,720 associations by consensus.

DNA replication initiation by DDX18 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →