DDX17

Across TCGA pan-cancer cohorts, DDX17 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DDX17 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DDX17 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDX17 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

HNSC, COAD, and LSCC are the cancer types where DDX17 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.185	1.000	.006	58	view →
COAD	DFS	Tertile	All	1.000	0.849	.021	54	view →
LSCC	DFS	Median	All	0.981	0.897	.006	17	view →
PDAC	DFS	Quartile	All	0.905	0.653	.003	16	view →
LUAD	OS	Tertile	III,IV	0.839	0.375	.031	5	view →
UCEC	DFS	Quartile	III,IV	0.462	0.855	.040	4	view →
GBM	OS	Quartile	All	0.572	0.251	.006	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DDX17–HNSC (DFS)

Open the HNSC breakdown →