DDX17

Across TCGA patient cohorts, DDX17 mutation is significantly associated with the RNA expression of many other genes, with 2,470 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX17-associated genes across cancer lineages are MIR5787, HSD17B1, and EFNB3. Each is linked with DDX17 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX17-to-partner and partner-to-DDX17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5787 grouped by DDX17-low versus DDX17-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX17→partner) and Y-score (partner→DDX17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR5787 →	+0.343	+4.630	<.001	.006	3	2
UCEC	HSD17B1 →	+0.267	+2.606	.002	<.001	3	2
UCEC	EFNB3 →	-1.076	-2.321	<.001	.001	3	2
UCEC	SEPSECS →	+0.402	+3.032	<.001	<.001	3	2
UCEC	TRIM23 →	+0.373	+1.912	.002	.004	3	2
UCEC	RARS1 →	+0.305	+2.169	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,470 associations by consensus.

MIR5787 by DDX17 expression — BRCA

Explore this box plot interactively →