DDX17

Across TCGA patient cohorts, DDX17 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX17-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and p90 RSK. Each is linked with DDX17 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX17-to-partner and partner-to-DDX17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DDX17-low versus DDX17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX17→partner) and Y-score (partner→DDX17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.505	+1.505	.012	.034	3	3
UCEC	ERK2 →	+0.231	+2.523	<.001	<.001	3	2
UCEC	p90 RSK →	+0.145	+2.459	.026	.018	3	2
UCEC	PDK1_pS241 →	+0.114	+1.847	.049	.007	3	2
UCEC	VHL →	-0.648	-1.678	.005	.021	3	2
UCEC	eEF2 →	+0.261	+2.321	.032	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by DDX17 expression — UCEC

Explore this box plot interactively →