DDX17

Across TCGA cell cohorts, DDX17 mutation is significantly associated with the RNA expression of many other genes, with 903 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDX17-associated genes across cancer lineages are AVP, SMIM33, and C4orf50. Each is linked with DDX17 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX17-to-partner and partner-to-DDX17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by DDX17-low versus DDX17-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX17→partner) and Y-score (partner→DDX17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	AVP →	+0.045	+4.736	<.001	.009	3	2
LARGE_INTESTINE	SMIM33 →	+0.576	+2.011	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.030	+5.357	<.001	.003	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.026	+4.662	<.001	.003	3	1
LARGE_INTESTINE	TOP3B →	+0.740	+2.502	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 903 associations by consensus.

AVP by DDX17 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →