DDX11L8

Across TCGA pan-cancer cohorts, DDX11L8 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DDX11L8 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher DDX11L8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DDX11L8 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

LIHC, ACC, and KIRC are the cancer types where DDX11L8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.546	0.728	<.001	68	view →
ACC	OS	Quartile	All	0.241	0.777	.002	41	view →
KIRC	DFS	Quartile	III,IV	0.185	0.506	.003	39	view →
UCEC	DFS	Median	All	0.582	0.655	.003	38	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
SKCM	OS	Tertile	IV	0.205	0.780	.001	31	view →
THCA	OS	Quartile	All	0.973	0.994	.002	31	view →
LUAD	DFS	Quartile	IV	0.423	0.802	.012	26	view →
UCS	DFS	Quartile	III,IV	0.536	0.187	.028	22	view →
DLBC	OS	Tertile	All	0.712	0.971	.006	18	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
KIRP	DFS	Tertile	III,IV	0.179	0.666	.018	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DDX11L8–LIHC (OS)

Open the LIHC breakdown →