Across TCGA pan-cancer cohorts, DDX11L5 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of DDX11L5’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where DDX11L5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX11L5 is over-expressed in tumor.
LUSC are the cancer types where DDX11L5 tumor–normal differential expression is most reproducible.