Across TCGA pan-cancer cohorts, DDX11L17 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DDX11L17’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where DDX11L17 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DDX11L17 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.
LIHC, KICH, and KIRC are the cancer types where DDX11L17 tumor–normal differential expression is most reproducible.