DDX11

Across TCGA pan-cancer cohorts, DDX11 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DDX11 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DDX11 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DDX11 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, LUAD, and UCEC are the cancer types where DDX11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.568	.001	49	view →
LUAD	DFS	Tertile	All	0.438	0.858	<.001	27	view →
UCEC	DFS	Median	All	1.000	0.907	.022	6	view →
CCRCC	DFS	Median	II,III,IV	0.115	1.000	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DDX11–LSCC (OS)

Open the LSCC breakdown →