DDX11

Across TCGA patient cohorts, DDX11 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX11-associated genes across cancer lineages are ATM, 4E-BP1, and ERK2. Each is linked with DDX11 in more than 2 cancer types. Because this analysis shows association rather than direction, both DDX11-to-partner and partner-to-DDX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DDX11-low versus DDX11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX11→partner) and Y-score (partner→DDX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.599	-2.700	<.001	.006	3	3
UCEC	4E-BP1 →	+0.331	+2.029	<.001	.017	3	3
UCEC	ERK2 →	+0.189	+1.502	.007	.030	3	2
UCEC	EGFR_pY1068 →	-0.257	-1.847	.005	.008	3	2
UCEC	PCNA →	+0.242	+2.584	.002	.010	3	2
UCEC	PKC-delta_pS664 →	-0.102	-2.321	.020	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by DDX11 expression — UCEC

Explore this box plot interactively →