DDX11

Across TCGA cell cohorts, DDX11 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,074 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DDX11-associated GO terms across cancer lineages are Signal transduction in response to DNA damage, DNA replication, and Leading strand elongation. Each is linked with DDX11 in more than 19 cancer types. Because this analysis shows association rather than direction, both DDX11-to-partner and partner-to-DDX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Signal transduction in response to DNA damage grouped by DDX11-low versus DDX11-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX11→partner) and Y-score (partner→DDX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Signal transduction in response to DNA damage →	+0.071	+0.909	.002	.006	3	20
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.120	+1.740	<.001	<.001	3	19
PANCREAS	Leading strand elongation →	+0.148	+0.907	<.001	<.001	3	19
BONE	Double-strand break repair →	+0.110	+2.361	<.001	<.001	3	19
BONE	Replication fork processing →	+0.105	+1.497	<.001	<.001	3	19
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.104	+1.497	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,074 associations by consensus.

Signal transduction in response to DNA damage by DDX11 expression — BREAST

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