DDX10

Across TCGA pan-cancer cohorts, DDX10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDX10 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DDX10 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DDX10 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where DDX10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.305	0.796	<.001	44	view →
PDAC	OS	Median	All	0.391	0.712	<.001	43	view →
LSCC	DFS	Median	II,III,IV	0.828	0.536	.012	10	view →
LUAD	DFS	Quartile	III,IV	0.826	0.162	.026	3	view →
HNSC	OS	Tertile	All	1.000	0.951	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDX10–CCRCC (DFS)

Open the CCRCC breakdown →