DDX10

Across TCGA patient cohorts, DDX10 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX10-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Paxillin, and PDCD4. Each is linked with DDX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX10-to-partner and partner-to-DDX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by DDX10-low versus DDX10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX10→partner) and Y-score (partner→DDX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.349	-1.510	.015	.008	3	2
UCEC	Paxillin →	+0.233	+1.775	.004	.007	3	2
UCEC	PDCD4 →	-0.384	-1.289	.010	.023	3	2
UCEC	PEA-15_pS116 →	+0.283	+1.502	.011	.027	3	2
UCEC	Bak →	+0.167	+1.362	.036	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.537	+1.522	.004	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

p38-MAPK_pT180_Y182 by DDX10 expression — UCEC

Explore this box plot interactively →