DDX10

Across TCGA cell cohorts, DDX10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,770 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDX10-associated GO terms across cancer lineages are RNA modification, Termination of RNA polymerase I transcription, and rRNA pseudouridine synthesis. Each is linked with DDX10 in more than 14 cancer types. Because this analysis shows association rather than direction, both DDX10-to-partner and partner-to-DDX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA modification grouped by DDX10-low versus DDX10-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX10→partner) and Y-score (partner→DDX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNA modification →	+0.067	+0.907	<.001	<.001	3	15
BONE	Termination of RNA polymerase I transcription →	+0.126	+0.996	<.001	.002	3	14
LUNG_SCLC	rRNA pseudouridine synthesis →	+0.132	+0.777	<.001	.001	3	14
BLOOD_Lymphoma	Ribosome biogenesis →	+0.127	+1.210	<.001	<.001	3	13
BLOOD_Lymphoma	Ribosomal small subunit biogenesis →	+0.128	+1.170	<.001	<.001	3	13
PANCREAS	Meiotic sister chromatid cohesion, centromeric →	+0.158	+0.854	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,770 associations by consensus.

RNA modification by DDX10 expression — LUNG_SCLC

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