DDX1

Across TCGA pan-cancer cohorts, DDX1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DDX1 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DDX1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DDX1 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where DDX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	24	view →
HNSC	OS	Quartile	IV	0.454	0.856	.002	18	view →
LSCC	DFS	Tertile	III,IV	0.495	0.918	.029	10	view →
GBM	DFS	Quartile	All	0.521	0.230	.001	6	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	6	view →
PDAC	OS	Quartile	All	0.462	0.283	.031	4	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DDX1–UCEC (OS)

Open the UCEC breakdown →