DDX1

Across TCGA patient cohorts, DDX1 mutation is significantly associated with the RNA expression of many other genes, with 2,716 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX1-associated genes across cancer lineages are HNRNPA1P72, RPS27P22, and RN7SL375P. Each is linked with DDX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX1-to-partner and partner-to-DDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPA1P72 grouped by DDX1-low versus DDX1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX1→partner) and Y-score (partner→DDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	HNRNPA1P72 →	+0.054	+4.544	<.001	.009	3	2
LIHC	RPS27P22 →	+0.144	+4.544	<.001	.009	3	2
CESC	RN7SL375P →	+0.148	+4.705	<.001	.003	3	2
CESC	MIR4478 →	+1.394	+4.996	<.001	.002	3	2
SKCM	RNA5SP404 →	+0.171	+4.343	<.001	<.001	3	2
CESC	MAGEB6 →	+0.288	+4.320	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,716 associations by consensus.

HNRNPA1P72 by DDX1 expression — LIHC

Explore this box plot interactively →