DDX1

Across TCGA patient cohorts, DDX1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDX1-associated genes across cancer lineages are eIF4E, ACC1, and p38-MAPK_pT180_Y182. Each is linked with DDX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDX1-to-partner and partner-to-DDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DDX1-low versus DDX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDX1→partner) and Y-score (partner→DDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.179	+2.906	.018	.001	3	2
UCEC	ACC1 →	+0.373	+2.472	.004	.010	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.447	-1.912	.005	.005	3	2
UCEC	p90 RSK_pT359_S363 →	-0.186	-2.000	.010	.029	3	2
UCEC	P-Cadherin →	-0.160	-3.807	.002	<.001	3	2
UCEC	PDCD4 →	-0.554	-2.321	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

eIF4E by DDX1 expression — UCEC

Explore this box plot interactively →