DDTL

Across TCGA pan-cancer cohorts, DDTL mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DDTL data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DDTL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DDTL expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where DDTL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.782	0.363	<.001	33	view →
LSCC	DFS	Median	II,III,IV	0.826	1.000	.002	15	view →
UCEC	OS	Median	II,III,IV	0.578	1.000	.011	12	view →
PDAC	DFS	Median	III,IV	0.529	0.241	.005	8	view →
HNSC	OS	Quartile	III,IV	0.956	0.838	.023	3	view →
LUAD	OS	Median	All	0.774	0.975	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DDTL–CCRCC (DFS)

Open the CCRCC breakdown →