DDTL

Across TCGA patient cohorts, DDTL RNA expression is significantly associated with the protein abundance of many other proteins, with 14,534 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDTL-associated proteins across cancer lineages are TRMT2A, GTSE1_S262, and HDHD5. Each is linked with DDTL in more than 5 cancer types. Because this analysis shows association rather than direction, both DDTL-to-partner and partner-to-DDTL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDTL versus TRMT2A in GBM, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DDTL→partner) and Y-score (partner→DDTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRMT2A →	+0.266	+0.434	<.001	<.001	3	6
LSCC	GTSE1_S262 →	+0.870	+0.600	<.001	<.001	3	4
GBM	HDHD5 →	+0.396	+0.392	.002	.002	3	4
HNSC	MORC2_S743 →	+0.601	+0.704	<.001	<.001	3	4
LSCC	XAB2 →	+0.236	+0.591	<.001	<.001	3	4
PDAC	NUP133 →	+0.133	+0.322	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,534 associations by consensus.

DDTL vs TRMT2A — GBM

Explore this scatter interactively →