DDTL

Across TCGA patient cohorts, DDTL protein abundance is significantly associated with the RNA expression of many other genes, with 12,137 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDTL-associated genes across cancer lineages are CDC20, CDCA8, and KIF23. Each is linked with DDTL in more than 7 cancer types. Because this analysis shows association rather than direction, both DDTL-to-partner and partner-to-DDTL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDTL versus CDC20 in UCEC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDTL→partner) and Y-score (partner→DDTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDC20 →	-1.283	-0.232	.002	.006	2	8
LUAD	CDCA8 →	-1.176	-0.259	<.001	<.001	3	7
BRCA	KIF23 →	-1.061	-0.397	<.001	.001	3	7
LUAD	UBE2C →	-1.773	-0.303	<.001	<.001	3	7
BRCA	CDKN3 →	-1.002	-0.386	<.001	<.001	3	6
LUAD	MYBL2 →	-1.603	-0.301	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,137 associations by consensus.

DDTL vs CDC20 — UCEC

Explore this scatter interactively →