DDTL

Across TCGA cell cohorts, DDTL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,930 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDTL-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and DNA topological change. Each is linked with DDTL in more than 12 cancer types. Because this analysis shows association rather than direction, both DDTL-to-partner and partner-to-DDTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by DDTL-low versus DDTL-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDTL→partner) and Y-score (partner→DDTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Symbiont-mediated disruption of host cellular anatomical structure →	+0.109	+0.839	.002	.002	3	13
URINARY_TRACT	Symbiont-mediated disruption of host anatomical structure →	+0.109	+0.839	.002	.002	3	13
URINARY_TRACT	DNA topological change →	+0.154	+1.185	<.001	<.001	3	13
SOFT_TISSUE	Negative regulation of macrophage chemotaxis →	+0.869	+1.280	.002	<.001	3	12
BONE	DNA replication proofreading →	+0.203	+1.083	.002	.001	3	12
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.201	+1.135	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,930 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by DDTL expression — URINARY_TRACT

Explore this box plot interactively →