Across TCGA patient cohorts, DDRGK1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDRGK1-associated genes across cancer lineages are MEK1, Rad50, and Caspase-7-cleavedD198. Each is linked with DDRGK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDRGK1-to-partner and partner-to-DDRGK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDRGK1→partner) and Y-score (partner→DDRGK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.410	+3.000	.041	.036	3	1
UCEC	Rad50 →	-0.276	-3.169	.037	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.992	+3.169	.002	.020	3	1
UCEC	ERK2 →	+0.260	+3.169	.014	.020	2	1
UCEC	c-Jun_pS73 →	-0.232	-3.169	.007	.020	1	1
UCEC	C-Raf →	+0.206	+3.169	.008	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

DDRGK1 survival (RNA) · tumor vs normal (RNA) · all DDRGK1 data types