Across TCGA patient cohorts, DDR1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDR1-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Jun_pS73, and Cyclin-B1. Each is linked with DDR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DDR1-to-partner and partner-to-DDR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDR1→partner) and Y-score (partner→DDR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.806	+2.434	<.001	.001	3	4
UCEC	c-Jun_pS73 →	-0.137	-3.156	.012	.018	3	3
UCEC	Cyclin-B1 →	+0.506	+3.459	.009	.005	3	3
UCEC	PCNA →	+0.185	+2.584	.013	.010	3	2
UCEC	PDCD4 →	-0.455	-1.896	.005	.015	3	2
UCEC	Shc_pY317 →	-0.128	-1.440	.015	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

DDR1 survival (RNA) · tumor vs normal (RNA) · all DDR1 data types