DDOST

Across TCGA pan-cancer cohorts, DDOST mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DDOST data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DDOST mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DDOST expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where DDOST mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.984	0.807	<.001	41	view →
CCRCC	DFS	Median	III,IV	0.494	0.862	<.001	37	view →
HNSC	OS	Median	III,IV	0.950	0.786	.004	14	view →
LSCC	OS	Median	II,III,IV	0.749	0.914	.027	5	view →
PDAC	OS	Median	All	0.716	0.924	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DDOST–LUAD (DFS)

Open the LUAD breakdown →