DDOST

Across TCGA patient cohorts, DDOST mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDOST-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and A-Raf_pS299. Each is linked with DDOST in more than 1 cancer types. Because this analysis shows association rather than direction, both DDOST-to-partner and partner-to-DDOST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by DDOST-low versus DDOST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDOST→partner) and Y-score (partner→DDOST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.684	+3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.314	-3.459	.012	.005	3	1
UCEC	A-Raf_pS299 →	-0.125	-3.169	.037	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.147	-2.321	.019	.035	3	1
UCEC	Notch1 →	+0.205	+2.321	.003	.035	3	1
UCEC	PCNA →	+0.260	+3.169	.016	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

p62 Lck ligand by DDOST expression — UCEC

Explore this box plot interactively →