DDOST

Across TCGA cell cohorts, DDOST mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DDOST-associated genes across cancer lineages are G6PC2, DEFA4, and BPIFA1. Each is linked with DDOST in more than 1 cancer types. Because this analysis shows association rather than direction, both DDOST-to-partner and partner-to-DDOST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PC2 grouped by DDOST-low versus DDOST-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDOST→partner) and Y-score (partner→DDOST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	G6PC2 →	+0.032	+3.658	<.001	.005	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPIFA1 →	+0.129	+3.688	.002	.002	3	1
LARGE_INTESTINE	FAM205A →	+0.022	+4.614	<.001	.002	3	1
LARGE_INTESTINE	WNT8A →	+0.018	+3.632	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

G6PC2 by DDOST expression — LARGE_INTESTINE

Explore this box plot interactively →