Across TCGA patient cohorts, DDO protein abundance is significantly associated with the RNA expression of many other genes, with 11,236 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDO-associated genes across cancer lineages are TBXAS1, POLR1B, and COLEC12. Each is linked with DDO in more than 3 cancer types. Because this analysis shows association rather than direction, both DDO-to-partner and partner-to-DDO results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDO→partner) and Y-score (partner→DDO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TBXAS1 →	+0.633	+0.414	.001	.001	3	4
HNSC	POLR1B →	-0.616	-0.838	.001	<.001	3	4
GBM	COLEC12 →	+0.819	+0.346	.007	<.001	3	4
LSCC	AGO2 →	-0.566	-0.294	<.001	<.001	3	4
GBM	TRIM28 →	-0.547	-0.390	<.001	<.001	3	4
LSCC	SLC39A6 →	-0.592	-0.271	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,236 associations by consensus.

Exploration

DDO survival (RNA) · tumor vs normal (RNA) · all DDO data types