Across TCGA patient cohorts, DDO mutation is significantly associated with the RNA expression of many other genes, with 3,518 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDO-associated genes across cancer lineages are CYFIP1, TUBGCP5, and SNORD66. Each is linked with DDO in more than 1 cancer types. Because this analysis shows association rather than direction, both DDO-to-partner and partner-to-DDO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDO→partner) and Y-score (partner→DDO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYFIP1 →	+0.529	+1.958	<.001	.003	3	2
UCEC	TUBGCP5 →	+0.480	+2.135	<.001	.002	3	2
HNSC	SNORD66 →	+0.447	+4.565	.004	.004	3	2
CESC	CPLX3 →	+0.019	+5.342	<.001	.002	3	2
LUAD	E2F6P3 →	+0.046	+3.531	.004	.007	3	2
LUAD	OR11H5P →	+0.032	+4.739	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,518 associations by consensus.

Exploration

DDO survival (RNA) · tumor vs normal (RNA) · all DDO data types