Across TCGA cell cohorts, DDO mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DDO-associated genes across cancer lineages are KRT73, KRTAP3-1, and OR10A6. Each is linked with DDO in more than 1 cancer types. Because this analysis shows association rather than direction, both DDO-to-partner and partner-to-DDO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDO→partner) and Y-score (partner→DDO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KRT73 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP3-1 →	+0.099	+4.807	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1
SKIN	GPR33 →	+0.012	+4.977	.002	.007	3	1
LUNG_NSCLC_LUAD	AGXT2 →	+0.025	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

DDO survival (RNA) · tumor vs normal (RNA) · all DDO data types