DDN

Across TCGA pan-cancer cohorts, DDN mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated DDN data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DDN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DDN expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC and GBM are the cancer types where DDN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.966	0.803	.010	17	view →
GBM	OS	Median	All	0.379	0.615	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

DDN–CCRCC (OS)

Open the CCRCC breakdown →