DDN

Across TCGA patient cohorts, DDN protein abundance is significantly associated with the RNA expression of many other genes, with 6,650 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DDN-associated genes across cancer lineages are CPXM2, TIMP3, and CTSG. Each is linked with DDN in more than 3 cancer types. Because this analysis shows association rather than direction, both DDN-to-partner and partner-to-DDN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDN versus CPXM2 in BRCA, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDN→partner) and Y-score (partner→DDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CPXM2 →	+1.386	+0.961	<.001	<.001	3	4
CCRCC	TIMP3 →	+1.499	+1.065	<.001	<.001	3	3
BRCA	CTSG →	+1.401	+0.937	<.001	<.001	3	3
CCRCC	MYOM1 →	+0.939	+0.905	<.001	<.001	3	3
BRCA	SRPX →	+1.009	+0.789	<.001	<.001	3	3
CCRCC	RGCC →	+1.178	+0.893	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,650 associations by consensus.

DDN vs CPXM2 — BRCA

Explore this scatter interactively →