DDN

Across TCGA patient cohorts, DDN mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDN-associated genes across cancer lineages are eIF4G, ERK2, and GATA6. Each is linked with DDN in more than 1 cancer types. Because this analysis shows association rather than direction, both DDN-to-partner and partner-to-DDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by DDN-low versus DDN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDN→partner) and Y-score (partner→DDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.365	+3.169	.032	.020	3	1
UCEC	ERK2 →	+0.349	+3.169	<.001	.020	3	1
UCEC	GATA6 →	-0.211	-2.992	.018	.036	3	1
UCEC	Rab11 →	-0.173	-3.169	.030	.020	3	1
UCEC	ASNS →	+0.483	+3.169	.015	.020	3	1
UCEC	Heregulin →	-0.170	-3.169	.012	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4G by DDN expression — UCEC

Explore this box plot interactively →