DDN

Across TCGA cell cohorts, DDN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,971 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DDN-associated GO terms across cancer lineages are Ribosomal small subunit biogenesis, Nucleolar large rRNA transcription by RNA polymerase I, and IMP biosynthetic process. Each is linked with DDN in more than 13 cancer types. Because this analysis shows association rather than direction, both DDN-to-partner and partner-to-DDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal small subunit biogenesis grouped by DDN-low versus DDN-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDN→partner) and Y-score (partner→DDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Ribosomal small subunit biogenesis →	+0.098	+1.119	.003	.005	2	14
BONE	Nucleolar large rRNA transcription by RNA polymerase I →	+0.136	+1.232	.005	.008	3	13
BLOOD_Myeloma	IMP biosynthetic process →	+0.183	+1.703	.003	.006	3	13
LUNG_SCLC	XMP metabolic process →	+0.165	+1.395	<.001	<.001	3	13
LUNG_SCLC	XMP biosynthetic process →	+0.165	+1.395	<.001	<.001	3	13
LUNG_SCLC	'de novo' XMP biosynthetic process →	+0.165	+1.395	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,971 associations by consensus.

Ribosomal small subunit biogenesis by DDN expression — BONE

Explore this box plot interactively →