DDIT4

Across TCGA patient cohorts, DDIT4 protein abundance is significantly associated with the RNA expression of many other genes, with 612 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DDIT4-associated genes across cancer lineages are RAB11A, BBC3, and TYK2. Each is linked with DDIT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DDIT4-to-partner and partner-to-DDIT4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DDIT4 versus RAB11A in LUAD, with a Pearson correlation of -0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDIT4→partner) and Y-score (partner→DDIT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAB11A →	-0.683	-0.613	.001	.009	3	1
LUAD	BBC3 →	-1.139	-0.736	.008	.004	3	1
LUAD	TYK2 →	-0.960	-0.586	.007	.002	3	1
LUAD	WIZ →	-0.953	-0.736	.003	.004	3	1
LUAD	MESD →	-0.425	-0.628	<.001	<.001	3	1
LUAD	ACYP1 →	-0.382	-0.628	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 612 associations by consensus.

DDIT4 vs RAB11A — LUAD

Explore this scatter interactively →