DDIAS

Across TCGA patient cohorts, DDIAS mutation is significantly associated with the RNA expression of many other genes, with 4,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDIAS-associated genes across cancer lineages are HAUS1, CDCA4, and PSMA3. Each is linked with DDIAS in more than 2 cancer types. Because this analysis shows association rather than direction, both DDIAS-to-partner and partner-to-DDIAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS1 grouped by DDIAS-low versus DDIAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDIAS→partner) and Y-score (partner→DDIAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HAUS1 →	+0.537	+1.970	<.001	<.001	3	3
SKCM	CDCA4 →	+0.588	+3.591	.004	.001	3	3
UCEC	PSMA3 →	+0.330	+3.914	.004	<.001	3	3
UCEC	CD274 →	+0.490	+1.652	<.001	.006	3	3
UCEC	UBR7 →	+0.705	+2.697	<.001	<.001	3	3
UCEC	TMX1 →	+0.593	+2.732	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,053 associations by consensus.

HAUS1 by DDIAS expression — UCEC

Explore this box plot interactively →