DDIAS

Across TCGA patient cohorts, DDIAS mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DDIAS-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and PCNA. Each is linked with DDIAS in more than 2 cancer types. Because this analysis shows association rather than direction, both DDIAS-to-partner and partner-to-DDIAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DDIAS-low versus DDIAS-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DDIAS→partner) and Y-score (partner→DDIAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EGFR_pY1068 →	-0.526	-3.000	.045	.036	3	3
UCEC	mTOR_pS2448 →	-0.147	-2.571	.006	.010	3	3
UCEC	PCNA →	+0.312	+3.169	<.001	<.001	3	3
LUAD	HER2_pY1248 →	-0.350	-2.983	.038	.034	3	2
LUAD	Annexin-1 →	+0.472	+3.000	.048	.036	3	2
UCEC	eIF4E →	+0.218	+3.000	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

EGFR_pY1068 by DDIAS expression — LUAD

Explore this box plot interactively →