DDIAS

Across TCGA cell cohorts, DDIAS RNA expression is significantly associated with the go_rna of many other GO terms, with 4,831 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DDIAS-associated GO terms across cancer lineages are Centromeric sister chromatid cohesion, DNA replication, and Nuclear chromosome segregation. Each is linked with DDIAS in more than 19 cancer types. Because this analysis shows association rather than direction, both DDIAS-to-partner and partner-to-DDIAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centromeric sister chromatid cohesion grouped by DDIAS-low versus DDIAS-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DDIAS→partner) and Y-score (partner→DDIAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Centromeric sister chromatid cohesion →	+0.180	+1.547	.006	<.001	3	20
BONE	DNA replication →	+0.156	+1.446	<.001	.002	3	20
BONE	Nuclear chromosome segregation →	+0.146	+1.459	.004	.004	3	20
STOMACH	Nuclear division →	+0.084	+1.117	<.001	<.001	3	19
OESOPHAGUS	Regulation of mitotic metaphase/anaphase transition →	+0.115	+1.153	.005	.002	3	19
SOFT_TISSUE	Regulation of chromosome organization →	+0.075	+1.107	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,831 associations by consensus.

Centromeric sister chromatid cohesion by DDIAS expression — OESOPHAGUS

Explore this box plot interactively →